Abstract
SLU-PP-332 activates estrogen receptor-related orphan receptors, increasing energy expenditure, fatty acid oxidation, and decreasing fat mass accumulation. The drug enhances mitochondrial function and cellular respiration in skeletal muscle cell lines, increases the expression of an estrogen receptor-related orphan receptor target gene, and enhances mitochondrial respiration in C2C12 myocytes. The drug also increases oxidative fibers in skeletal muscle and improves exercise endurance in C57BL/6J mice.