Nickan Research Institute Journal of Renal Endocrinology 2423-6438 11 1 2025 01 01 Kidney injury following JN.1; a mini-review on current evidence e25192 e25192 10.34172/jre.2025.25192 EN Yassamin Rabiei https://orcid.org/0000-0002-1283-4403 Journal Article 10.34172/jre.2025.25192 2024 03 23 2025 05 23 The SARS-CoV-2 JN.1 variant, a descendant of the Omicron BA.2.86 lineage, emerged as a globally dominant COVID-19 strain by early 2024. This virus characterized by heightened transmissibility and immune evasion, which represents as an evolution in the virus’s ability to adapt across with maintaining lower severity versus earlier variants. Since direct evidence on JN.1 and renal involvement is lacking, the variant is expected to cause kidney injury through the well-characterized SARS-CoV-2 mechanisms of direct renal infection and systemic inflammatory damage observed in COVID-19 patients in general.