Nickan Research Institute Journal of Renal Endocrinology 2423-6438 11 1 2025 01 01 Obesity, diabetes, and cancer; a triad of interconnected risks and emerging evidence e25196 e25196 10.34172/jre.2025.25196 EN Hafez Mohammadhassanzadeh https://orcid.org/0000-0003-1687-4418 Zeinab Aliyari Serej https://orcid.org/0000-0002-4355-1908 Journal Article 10.34172/jre.2025.25196 2025 03 11 2025 05 31 Obesity has become a major risk factor for different types of cancer, and highlights research emphasizes the impact of inflammation related to obesity in this connection. Chronic low-grade inflammation associated with excess adipose tissue can disrupt metabolic signaling and immune responses, which may facilitate the tumorigenesis.