Nickan Research Institute Journal of Renal Endocrinology 2423-6438 11 1 2025 01 01 Impact of vitamin D therapy on vascular consistency e25200 e25200 10.34172/jre.2025.25200 EN Kamran Shirbache https://orcid.org/0000-0002-9042-9534 Ali Shirbacheh https://orcid.org/0000-0001-5334-0736 Journal Article 10.34172/jre.2025.25200 2025 04 03 2025 06 02 The impact of vitamin D on vascular health is dualistic, with protective effects at physiological levels—such as enhanced endothelial function and reduced oxidative stress—alongside potential harmful effects at excessive doses or in disease states, such as vascular calcification and smooth muscle cell dysfunction. Targeting vitamin D receptor (VDR) signaling pathways may offer therapeutic strategies for cardiovascular diseases; however, dosage and patient-specific factors, such as chronic kidney disease and vitamin D status, should be carefully considered.