Nickan Research Institute Journal of Renal Endocrinology 2423-6438 5 1 2019 01 01 Rosai-Dorfman disease; a case report and review of the literature e10 e10 EN Shakiba Hassanzadeh https://orcid.org/0000-0002-5091-5191 Parto Nasri https://orcid.org/0000-0002-9596-8860 Mohammadreza Khosravifarsani https://orcid.org/0000-0003-4271-7846 Journal Article 2019 10 16 2019 12 02 Rosai-Dorfman disease (RDD) also known as sinus histiocytosis with massive lymphadenopathy (SHML) is a rare idiopathic and benign disorder. We report a case of a previously healthy 44-year-old female patient who first presented with painless enlargement of the submandibular and parotid glands. She, later on, experienced multiple recurrences. The diagnosis of RDD in this patient was confirmed with pathology examinations and immunohistochemistry evaluations.