Nickan Research Institute Journal of Renal Endocrinology 2423-6438 4 1 2018 01 01 A case of thyroid storm; a challenge to diagnose e18 e18 EN Zahra Freidooni Majid Forootan Journal Article 2018 04 15 2018 05 20 Thyroid storm is a malignant presentation of hyperthyroidism which has a mortality rate of 10% to 30% around the world. Lack of direct laboratory test has made the diagnosis of thyroid storm a challenge in clinical practice. There is no consensus about the diagnosis of thyroid storm and the clinical view, which experience of the practitioner is vital for proper diagnosis of this situation. Early diagnosis may lead to fast initiation of aggressive treatment to prevent mortality. In this report, we present a case of thyroid storm which was first approached based on her gastrointestinal (GI) symptoms and re-visited in our center because of no improvement in her GI symptoms and also addition of CNS manifestations.