Nickan Research Institute Journal of Renal Endocrinology 2423-6438 9 1 2023 01 01 Renal effects of hydatidiform mole and choriocarcinoma e25097 e25097 10.34172/jre.2023.25097 EN Hamid Nasri https://orcid.org/0000-0003-1673-5741 Journal Article 10.34172/jre.2023.25097 2023 04 13 2023 06 08 Molar pregnancy is an abnormal growth of trophoblastic tissue in the uterus. It can be either complete or partial. In complete moles, the development of the fetus is absent, while partial moles contain an abnormal gestational sac. Choriocarcinoma is a malignant form that arise from molar tissue. Hydatidiform mole and choriocarcinoma are rare and complicated diseases with numerous pathological conditions that can lead to significant kidney damage. Proteinuria, nephrotic syndrome, preeclampsia, decreased glomerular filtration rate, interstitial inflammation, crescentic glomerulonephritis, and thrombosis of the renal veins are the commonly encountered renal disorders with these diseases. Early intervention and treatment during pregnancy minimize these risks and lessen the risk of chronic kidney disease or end-stage renal failure. A multidisciplinary team approach involving obstetricians, nephrologists, pathologists, gynecologists, and radiologists is necessary for optimal management.