Nickan Research Institute Journal of Renal Endocrinology 2423-6438 9 1 2023 01 01 Muscle-kidney crosstalk; the role of myokines e25129 e25129 10.34172/jre.2023.25129 EN Mohammad Reza Moonesan https://orcid.org/0000-0003-4351-0732 Journal Article 10.34172/jre.2023.25129 2023 04 10 2023 07 15 Muscle-kidney crosstalk refers to the communication and interaction between skeletal muscle tissue and the kidneys. One important aspect of this crosstalk is the role of myokines. Myokines are a class of bioactive molecules that are released by contracting skeletal muscles. They act as signaling molecules that can mediate communication between muscle tissue and various target organs, including the kidneys. Myokines are involved in regulating various physiological processes and have been shown to have both local and systemic effects.